Think Twice Before Using Ozempic—New Study Links It To Mood Disorders And Brain Changes (Image Credits: iStock)
Widely used weight loss drugs like Ozempic and Mounjaro have become increasingly popular for their ability to curb appetite and support weight loss. Belonging to a class of medications called GLP-1 receptor agonists, they were originally developed to treat type 2 diabetes but are now frequently prescribed off-label for weight loss. These drugs work by mimicking incretin, a hormone that helps regulate blood sugar levels and appetite.
By activating GLP-1 receptors in the brain, these medications help users feel full more quickly and reduce cravings, making it easier to eat less. However, alongside their success stories, these drugs come with a growing list of potential side effects and, now, concerns about their impact on mental health.
Common physical side effects include nausea, vomiting, diarrhoea, constipation, stomach pain, and fatigue. More serious risks involve kidney problems, gallbladder issues, pancreatitis, vision loss, and even thyroid tumours in rare cases.
Now, a new study published in Current Neuropharmacology has sounded the alarm on potential mental health risks associated with GLP-1 agonists. The research shows how these drugs may interact with genes involved in mood regulation and dopamine signalling, including DRD3, BDNF, and CREB1—genes linked to depression, anxiety, and suicidal ideation.
“Chronic use may disrupt dopamine signalling and increase the risk of depression and suicidal thoughts,” warned the researchers. The study found that while GLP-1 agonists might be helpful for individuals with hyperdopaminergic conditions (too much dopamine activity), they may be harmful for those with low dopamine levels, potentially increasing mental health issues.
“This study should not be ignored, despite the hype surrounding the positive clinical outcomes of GLP-1 receptor agonists,” said senior author Dr Kenneth Blum of Western University Health Sciences and Ariel University. Co-author and addiction psychiatry expert Dr. Mark S. Gold added, “The paper provides critical evidence for reevaluating the widespread use of GLP-1 receptor agonists. The FDA and other regulatory agencies should carefully consider our findings.”
For those looking to manage their weight and appetite without medication, several natural strategies may help:
Natural Ways to Control Appetite and Lose Weight:
1. Eat More Protein and Fibre
These nutrients help keep you full for longer and reduce cravings. Eggs, lentils, beans, nuts, and whole grains are great options.
2. Stay Hydrated
Sometimes we mistake thirst for hunger. Drinking a glass of water before meals may help reduce food intake.
3. Practice Mindful Eating
Slowing down, avoiding distractions, and savouring your food can prevent overeating and help you recognise true hunger cues.
4. Get Enough Sleep
Lack of sleep affects hunger hormones like ghrelin and leptin, often increasing cravings and appetite.
5. Manage Stress
Chronic stress can trigger emotional eating. Techniques like meditation, deep breathing, or physical activity can help.
6. Regular Exercise
Physical activity not only burns calories but also improves mood and supports metabolism.
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